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Phenotypes Associated with This Genotype
Genotype
MGI:3695134
Allelic
Composition		 Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl10tm1Adl mutation (2 available); any Cxcl10 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:75584 )
• 25% decrease in the spleen after mouse hepatitis virus infection
abnormal T cell physiology ( J:75584 )
• decreased CNS levels of both CD4+ and CD8+ T cells after mouse hepatitis virus infection
abnormal interferon level ( J:75584 )
• decreased IFN-gamma in response to mouse hepatitis virus
increased susceptibility to Hepadnaviridae infection ( J:75584 )
• greater sensitivity to mouse hepatitis virus
• titers similar to controls after 7 days but significantly higher than controls 12 days after infection

nervous system
demyelination ( J:75584 )
• level of demyelination reduced 12 days after infection with mouse hepatitis virus

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:75584 )
• 25% decrease in the spleen after mouse hepatitis virus infection
abnormal T cell physiology ( J:75584 )
• decreased CNS levels of both CD4+ and CD8+ T cells after mouse hepatitis virus infection

homeostasis/metabolism
abnormal interferon level ( J:75584 )
• decreased IFN-gamma in response to mouse hepatitis virus

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory