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Phenotypes Associated with This Genotype
Genotype
MGI:3695133
Allelic
Composition
Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic
Background
involves: 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl10tm1Adl mutation (2 available); any Cxcl10 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA
• proliferative responses after sensitization to specific antigens is also reduced
• reduced levels of antigen specific IgG2a in serum when immunized with OVA
• secretion of IFN-gamma reduced 60%

hematopoietic system
• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA
• proliferative responses after sensitization to specific antigens is also reduced
• reduced levels of antigen specific IgG2a in serum when immunized with OVA

cellular
• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA
• proliferative responses after sensitization to specific antigens is also reduced


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory