Phenotypes Associated with This Genotype

Genotype
MGI:3694012

• Allelic Composition: Lep^ob/Lep^ob; Npy2r^tm1.1Hhz/Npy2r^tm1.1Hhz
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased pancreas weight ( J:107169 )

• 0.37 g vs 0.29 in wild-type

decreased lean body mass ( J:107169 )

• decreased (19.8 g, 43% of body weight) compared to wild-type (25.5 g 87% of body weight); lean mass is increased significantly compared to Lep homozygotes (16 g, 33% of body weight)

increased body weight ( J:107169 )

• higher than wild-type and similar to in Lep^ob homozygotes

increased kidney weight ( J:107169 )

• 0.46 g vs 0.41 g in wild-type; size is reduced compared to Lep homozygotes

increased liver weight ( J:107169 )

• 4.45 g vs 1.44 g in wild-type

homeostasis/metabolism

abnormal circulating glucose level ( J:107169 )

• levels are similar to wild-type, but greatly decreased from levels found in Lep^ob homozygotes

decreased circulating testosterone level ( J:107169 )

• significantly lower (5.2 nmol/l) compared to wild-type (14.2 nmol/l)

decreased circulating corticosterone level ( J:107169 )

• levels are decreased compared to Lep homozygotes, and normalized compared to wild-type levels

abnormal circulating insulin level ( J:107169 )

• circulating insulin levels are not significantly higher than wild-type but are significantly decreased from Lep^ob homozygotes

increased circulating cholesterol level ( J:107169 )

• 6.56 mmol/l vs 3.54 mmol/l in wild-type

increased circulating triglyceride level ( J:107169 )

• 2.86 mmol/l vs 1.62 mmol/l in wild-type

behavior/neurological

polyphagia ( J:107169 )

endocrine/exocrine glands

increased pancreas weight ( J:107169 )

• 0.37 g vs 0.29 in wild-type

decreased testis weight ( J:107169 )

♂ • testes weigh 0.20 g compared to 0.33 g in wild-type

adipose tissue

abnormal adipose tissue amount ( J:107169 )

• combined white adipose tissue mass (WAT) is higher than wild-type but significantly lower than in Lep^ob homozygotes (WAT % body weight - wild-type 2.32%, Lep - 8.01, Npy2r, Lep double homozygotes - 6.88%)

decreased epididymal fat pad weight ( J:107169 )

• epididymal fat depot weight is significantly decreased compared to those of Lep^ob homozygotes

decreased mesenteric fat pad weight ( J:107169 )

• mesenteric fat depot weight is significantly decreased compared to those of Lep^ob homozygotes

reproductive system

decreased testis weight ( J:107169 )

♂ • testes weigh 0.20 g compared to 0.33 g in wild-type

female infertility ( J:76479 )

♀ • no females can produce offspring

male infertility ( J:76479 , J:107169 )

♂ • no males can produce offspring (J:76479)

♂ • no males could produce offspring (J:107169)

digestive/alimentary system

abnormal intestine morphology ( J:107169 )

• intestinal hypertrophy is attenuated compared to Lep^ob homozygotes (weight - 1.61 g vs 1.89 g in Lep^ob mice) but is still much greater than wild-type (1.61 g vs 1.03 g; intestine length 43 cm vs 33 cm in wild-type)

liver/biliary system

increased liver weight ( J:107169 )

• 4.45 g vs 1.44 g in wild-type

renal/urinary system

increased kidney weight ( J:107169 )

• 0.46 g vs 0.41 g in wild-type; size is reduced compared to Lep homozygotes