Phenotypes Associated with This Genotype

Genotype
MGI:3693616

• Allelic Composition: Ifngr1^tm1Agt/Ifngr1^tm1Agt
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:63815 )

• in vesicular somatitis virus (VSV)-infected mice

immune system

increased splenocyte proliferation ( J:99347 )

• splenocytes proliferate against the antigen and a mitogen more vigorously than those from wild-type

decreased IgG2a level ( J:63815 )

• in trinitrophenyl-conjugated ovalbumin-treated mice

decreased IgG3 level ( J:63815 )

• in trinitrophenyl-conjugated ovalbumin-treated mice

abnormal cytotoxic T cell physiology ( J:63815 )

• mice exhibit a slightly reduced CTL response against lymphocytic choriomeningitis virus (LCMV) infection with enhanced viral replication compared with similarly treated wild-type mice

increased interferon-gamma secretion ( J:99347 )

• stimulation of splenocytes with an antigen or a mitogen induces a higher production of IFN-gamma than in wild-type

increased interleukin-6 secretion ( J:99347 )

• stimulation of splenocytes with an antigen induces a higher production of IL-4, IL-6, IL-13 and IFN-gamma than in wild-type

• stimulation of splenocytes with a mitogen induces a higher production of IL-13

decreased susceptibility to experimental autoimmune myasthenia gravis ( J:53577 )

• following induction of experimental myasthenia gravis, mice exhibit less severe disease compared with wild-type mice

increased susceptibility to experimental autoimmune uveoretinitis ( J:99347 )

• exhibit increased incidence and severity of induced experimental autoimmune uveoretinitis compared to wild-type (59.3% vs. 40% of wild-type)

• upon uveoretinitis induction, see a significant infiltration of eosinophils into the eyes compared to wild-type

increased susceptibility to bacterial infection ( J:63815 )

• following infection with Listeria monocytogenes, mice exhibit 100-fold increase in bacterial titers in the liver and 10-fold in the spleen compared to in similarly treated wild-type mice

increased susceptibility to Riboviria infection ( J:63815 )

• mice infected with vesicular somatitis virus (VSV) exhibit a 100- to 1000-fold increase in viral titers and increased lethality compared with similarly treated wild-type mice

• mice exhibit a slightly reduced CTL response against lymphocytic choriomeningitis virus (LCMV) infection with enhanced viral replication compared with similarly treated wild-type mice

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:63815 )

• in vesicular somatitis virus (VSV)-infected mice

neoplasm

abnormal tumor susceptibility ( J:138466 )

• tumor growth in tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells is minimally delayed, and develop progressive disease

liver/biliary system

liver/biliary system phenotype ( J:120559 )

N • mice show no liver injury on treatment with HBsAg-specific Th1 cells and HBsAg

hematopoietic system

increased splenocyte proliferation ( J:99347 )

• splenocytes proliferate against the antigen and a mitogen more vigorously than those from wild-type

decreased IgG2a level ( J:63815 )

• in trinitrophenyl-conjugated ovalbumin-treated mice

decreased IgG3 level ( J:63815 )

• in trinitrophenyl-conjugated ovalbumin-treated mice

abnormal cytotoxic T cell physiology ( J:63815 )

• mice exhibit a slightly reduced CTL response against lymphocytic choriomeningitis virus (LCMV) infection with enhanced viral replication compared with similarly treated wild-type mice

cellular

increased splenocyte proliferation ( J:99347 )

• splenocytes proliferate against the antigen and a mitogen more vigorously than those from wild-type