Phenotypes Associated with This Genotype

Genotype
MGI:3693516

• Allelic Composition: Fyn^tm1Yik/Fyn^tm1Yik; Ptk2^tm1Lfr/Ptk2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus cortex atrophy ( J:110771 )

• atrophy of the thymic cortex

decreased thymocyte number ( J:110771 )

• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age

abnormal T cell differentiation ( J:110771 )

• impaired development of CD4+CD8+ thymocytes

decreased double-positive T cell number ( J:110771 )

• exhibit a reduction in double-positive thymocytes coincident with cortical atrophy

hematopoietic system

thymus cortex atrophy ( J:110771 )

• atrophy of the thymic cortex

decreased thymocyte number ( J:110771 )

• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age

abnormal T cell differentiation ( J:110771 )

• impaired development of CD4+CD8+ thymocytes

decreased double-positive T cell number ( J:110771 )

• exhibit a reduction in double-positive thymocytes coincident with cortical atrophy

endocrine/exocrine glands

thymus cortex atrophy ( J:110771 )

• atrophy of the thymic cortex

decreased thymocyte number ( J:110771 )

• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age