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Phenotypes Associated with This Genotype
Genotype
MGI:3693492
Allelic
Composition		 Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwLon)96Btla mutation (1 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:58050 )
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

homeostasis/metabolism
amyloid beta deposits ( J:58050 )
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory