Phenotypes Associated with This Genotype

Genotype
MGI:3693489

• Allelic Composition: Tg(APPSw)40Btla/0; Tg(PSEN1H163R)G9Btla/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:58050 )

• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice

• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months

homeostasis/metabolism

amyloid beta deposits ( J:58050 )

• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice

• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months