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Phenotypes Associated with This Genotype
Genotype
MGI:3693199
Allelic
Composition		 Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm2.1Grid mutation (0 available); any Jag1 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:115783 )
• all homozygous embryos are necrotic by E11.5

embryo
abnormal vitelline vascular remodeling ( J:115783 )
• homozygotes exhibit yolk sac vascular remodeling defects; most show vascular defects by E10.5

cardiovascular system
distended pericardium ( J:115783 )
• an enlarged pericardial sac is often seen in homozygotes

nervous system

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory