Phenotypes Associated with This Genotype

Genotype
MGI:3693130

• Allelic Composition: Tg(H2-K-BCL2)1Josd/0
• Genetic Background: involves: C57BL/6 * C57BL/Ka * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased mortality induced by ionizing radiation ( J:80894 )

• exhibit increased resistance to lethal challenges of x-ray irradiation, showing delayed death after irradiation compared to wild-type

hematopoietic system

abnormal hematopoietic system morphology/development ( J:80894 )

• hematopoietic populations, such as mature B- and T-cells, natural killer cells, myeloid cells, erythroid cells, and stem cells, show increased resistance to the effects of irradiation

enlarged thymus ( J:80894 )

enlarged spleen ( J:80894 )

increased leukocyte cell number ( J:80894 )

• increase in the number of circulating white blood cells

increased hematopoietic stem cell number ( J:80894 )

• increase in the number of hematopoietic stem cells

cellular

decreased cellular sensitivity to X-ray irradiation ( J:80894 )

• exhibit increased resistance to lethal challenges of x-ray irradiation, showing an increase in the radioresistance of individual cells, and an increase in the size of certain critically important cell populations, such as the hematopoietic stem cells

immune system

increased leukocyte cell number ( J:80894 )

• increase in the number of circulating white blood cells

abnormal lymph organ size ( J:80894 )

• 2- to 5-fold increase in size of lymphoid organs

enlarged thymus ( J:80894 )

enlarged spleen ( J:80894 )

enlarged lymph nodes ( J:80894 )

homeostasis/metabolism

decreased mortality induced by ionizing radiation ( J:80894 )

• exhibit increased resistance to lethal challenges of x-ray irradiation, showing delayed death after irradiation compared to wild-type

endocrine/exocrine glands

enlarged thymus ( J:80894 )

growth/size/body

enlarged spleen ( J:80894 )