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Phenotypes Associated with This Genotype
Genotype
MGI:3693009
Allelic
Composition		 Ightm1Kplm/Ightm4Cgn
Tg(Igk-V4CH27)1-2Shc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (47 available)
Ightm4Cgn mutation (0 available); any Igh mutation (47 available)
Tg(Igk-V4CH27)1-2Shc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:115292 )
• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

immune system
increased B cell number ( J:115292 )
• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory