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Phenotypes Associated with This Genotype
Genotype
MGI:3692536
Allelic
Composition		 Mc4rtm1Lowl/Mc4rtm1Lowl
Tg(Sim1-cre)2Lowl/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (44 available)
Tg(Sim1-cre)2Lowl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:115192 )
• mice expressing the transgene only in the posterior hypothalamus (PH) and having reactivated Mc4r in that region show no amelioration of obesity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory