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Phenotypes Associated with This Genotype
Genotype
MGI:3691620
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• circulating VLDL/LDL cholesterol levels are increased compared to in Apobec1tm1Chan homozygotes and wild-type mice
• LDL clearance is slowed
• when fed a chow diet or Western-type diet for 2 and 4 weeks, mice exhibit increased serum cholesterol levels compared to in Apobec1tm1Chan homozygotes and wild-type mice (J:48202)
• plasma cholesterol level is 196mg/dl on a normal diet (J:84694)
• increased plasma cholesterol levels after 20 weeks on Western diet (J:228420)
• levels are higher than those exhibited by in transgenic Tg(Alb-MYLIP*)1Pton mice after 30 weeks on Western diet (J:228420)
• on a chow diet, plasma LDL levels were higher than both those of wild-type mice and Ldlrap1tm1Her homozygous mutant mice (J:84694)
• plasma LDL levels become further elevated on high cholesterol diets (J:84694)
• male mice have a marked increase in plasma LDL cholesterol compared to wild-type (J:114949)
• in wild-type mice parabiosed with Ldlr-null mice (resulting in shared circulation), plasma total cholesterol levels did not increase significantly over pre-surgery levels (J:114949)
• plasma levels are increased 2.5 fold relative to controls (J:169834)
• when fed a chow diet or a Western-type diet for 2 and 4 weeks, mice exhibit increased serum triglyceride levels compared to in Apobec1tm1Chan homozygotes and wild-type mice

cardiovascular system
• mice develop atherosclerotic lesions after 20 weeks on Western diet
• total lesion area is larger when compared to lesion area in transgenic Tg(Alb-MYLIP*)1Pton mice after 30 weeks on Western diet

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial hypercholesterolemia DOID:13810 OMIM:143890
J:84694


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory