Phenotypes Associated with This Genotype

Genotype
MGI:3691085

• Allelic Composition: Cd3e^tm1Lov/Cd3e^tm1Lov
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell morphology ( J:72144 )

• single positive (SP) thymocytes are absent

• mature SP T cells are absent from periphery

• alpha/beta and gamma/delta TCR complexes are undetectable in thymus and lymphoid organs

increased double-negative T cell number ( J:72144 )

• all thymocytes present are DN

decreased double-positive T cell number ( J:72144 )

• DP thymocytes are absent

arrested T cell differentiation ( J:72144 )

• development is arrested at CD44^-/lo stage

immune system

abnormal T cell morphology ( J:72144 )

• single positive (SP) thymocytes are absent

• mature SP T cells are absent from periphery

• alpha/beta and gamma/delta TCR complexes are undetectable in thymus and lymphoid organs

increased double-negative T cell number ( J:72144 )

• all thymocytes present are DN

decreased double-positive T cell number ( J:72144 )

• DP thymocytes are absent

arrested T cell differentiation ( J:72144 )

• development is arrested at CD44^-/lo stage