Phenotypes for Fas Tnfrsf1a MGI:3690543 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fas^tm1Cgn/Fas^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^tm1Cgn mutation (1 available); any Fas mutation (83 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )

• reduction in the onset and severity, but not incidence of experimental autoimmune encephalomyelitis (EAE) induced by injection of MOG p35-55

• about a 75% reduction in oligodendrocyte apoptosis after EAE induction compared to wild-type mice

• inflammation after EAE induction is also reduced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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