Phenotypes for Fas Mog Tnfrsf1a MGI:3690542 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fas^tm1Cgn/Fas^tm1Cgn Mog^tm1(cre)Gkl/Mog⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^tm1Cgn mutation (1 available); any Fas mutation (82 available)
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:114741 )

N	• B and T cell distribution in the lymph nodes is normal • the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )

• mice are almost completely resistant to induction of experimental autoimmune encephalomyelitis (EAE) by injection of MOG p35-55

• almost no oligodendrocyte apoptosis after EAE induction unlike in wild-type mice

• reduction in demyelination and inflammation after induction of EAE is greater than in mutant mice wild-type for Tnfrsf1a

• 24 days after induction of EAE, minimal axonal injury is seen in spinal cords

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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