Phenotypes Associated with This Genotype

Genotype
MGI:3689892

• Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:82881 )

• 3-fold fewer goblet cells are found compared to wild-type

hematopoietic system

decreased eosinophil cell number ( J:82881 )

• reduction in eosinophilia is observed compared to wild-type

immune system

decreased eosinophil cell number ( J:82881 )

• reduction in eosinophilia is observed compared to wild-type

abnormal interleukin secretion ( J:82881 )

• mutants show reduced production of IL-4, IL-5, and IL-9

decreased interleukin-4 secretion ( J:82881 )

decreased interleukin-5 secretion ( J:82881 )

decreased interleukin-9 secretion ( J:82881 )

granulomatous inflammation ( J:82881 , J:113543 )

• reduction in granuloma volume is observed compared to wild-type, after infection with Schistosoma eggs (J:82881)

• primary granuloma formation and volumes after Schistosoma infection are reduced by >50% compared to wild-type (J:113543)

• volumes of secondary granulomas after second exposure with parasite eggs are reduced by ~50% compared to wild-type (J:113543)

increased susceptibility to parasitic infection ( J:113543 )

• primary granuloma formation and volumes after Schistosoma infection are reduced by >50% compared to wild-type

• volumes of secondary granulomas after second exposure with parasite eggs are reduced by ~50% compared to wild typ

respiratory system

pulmonary fibrosis ( J:82881 )

• fibrosis is reduced compared to wild-type

cellular

abnormal intestinal goblet cell morphology ( J:82881 )

• 3-fold fewer goblet cells are found compared to wild-type