Phenotypes Associated with This Genotype

Genotype
MGI:3689370

• Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx; Tg(Ins2-Cxcl13)1Cys/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:110548 )

• frequency of pancreatic infiltrates is same as in wild-type transgenic littermates, but size of infiltrate is markedly reduced; no large infiltrates are detected and 50% fewer medium infiltrates are observed

• deficiency in accumulation of T cells and dendritic cells in infiltrates compared to wild-type transgenic mice is seen

immune system

abnormal lymph organ development ( J:110548 )