Phenotypes Associated with This Genotype

Genotype
MGI:3689217

• Allelic Composition: Dnai7^{Gt(VICTR21)709Lex}/Dnai7^{Gt(VICTR21)709Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:111629 )

• 6X more tumors/mouse after treatment with urethane than seen in C57BL/6J (resistant) controls

increased lung adenoma incidence ( J:111629 )

increased lung adenocarcinoma incidence ( J:111629 )

• 29.1% of mice develop lung adenocarcenomas

• frequent invasion into bronchioles causing blockage

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:111629 )

• 6X more tumors/mouse after treatment with urethane than seen in C57BL/6J (resistant) controls

respiratory system

increased lung adenoma incidence ( J:111629 )

increased lung adenocarcinoma incidence ( J:111629 )

• 29.1% of mice develop lung adenocarcenomas

• frequent invasion into bronchioles causing blockage