Phenotypes for Cd74 H2-DMa MGI:3689121 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Liz/H2-DMa^tm1Liz
Genetic Background	involves: 129S/SvEv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (5 available); any Cd74 mutation (38 available)
H2-DMa^tm1Liz mutation (0 available); any H2-DMa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:113714 )

• double mutants display significant defects in CD4+ T cell development; numbers of CD4+ T cells in the thymus and periphery are greatly reduced compared to wild-type

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:113714 )

• double mutants display significant defects in CD4+ T cell development; numbers of CD4+ T cells in the thymus and periphery are greatly reduced compared to wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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