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Phenotypes Associated with This Genotype
Genotype
MGI:3689001
Allelic
Composition		 Cd74tm1Liz/Cd74tm1Liz
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Liz mutation (5 available); any Cd74 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal antigen presentation via MHC class II ( J:111565 )
• mutants display isotype-specific antigen presentation defects; MHC Ak-restricted antigen presentation is reduced compared to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory