Phenotypes Associated with This Genotype

Genotype
MGI:3688838

• Allelic Composition: Cd74^tm1Liz/Cd74^tm1Liz
• Genetic Background: B6.129S-Cd74^tm1Liz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:28966 )

• lymph node cells show significantly lower proliferative responses to immunization with keyhole limpet cyanin (KLH) compared to wild-type

decreased CD4-positive, alpha-beta T cell number ( J:28966 )

• significant reduction in numbers of mature CD4+CD8- thymocytes in thymus and periphery is seen compared to wild-type

abnormal T-helper 1 physiology ( J:125654 )

• in vivo, Th1 response to MOG is absent unlike in wild-type mice

• in vitro, lymph node cells from mice receiving wild-type MOG T cells exhibit reduced Th1 recall response compared with similarly treated wild-type mice

• in vivo, Th1 response to PLP is reduced compared to in wild-type mice

• in vitro, the frequency of Th1 recall response is greater than in H2-Dma^tm1Luc homozygotes

decreased susceptibility to type IV hypersensitivity reaction ( J:125654 )

• dramatically compared to in wild-type mice when wild-type MOG T cells are transferred

abnormal antigen presentation ( J:125654 )

• antigen presenting cells cannot process and present recombinant MOG protein unlike wild-type cells

abnormal antigen presentation via MHC class II ( J:28966 )

• class II molecules are relatively ineffective for presentation of native protein antigens

abnormal level of surface class II molecules ( J:28966 )

• mutants expressed greatly reduced amounts of class II on spleen cells compared to wild-type

defective assembly of class II molecules ( J:28966 )

• in spleen cells, immature alpha and beta chains exhibiting no evidence of having been exported past the cis-Golgi are observed, whereas compact alpha/beta dimers efficiently transported past the cis-Golgi are produced by Cd74^tm2Liz-deficient cells; floppy conformers are seen, compared to compact dimers in wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:125654 )

• whether MOG-primed or adoptively transferred with MOG-specific T blasts, mice fail to develop symptoms of experimental autoimmune encephalomyelitis (EAE) unlike wild-type mice

• PLP-treated mice fail to develop EAE unlike similarly treated wild-type mice

hematopoietic system

decreased T cell proliferation ( J:28966 )

• lymph node cells show significantly lower proliferative responses to immunization with keyhole limpet cyanin (KLH) compared to wild-type

decreased CD4-positive, alpha-beta T cell number ( J:28966 )

• significant reduction in numbers of mature CD4+CD8- thymocytes in thymus and periphery is seen compared to wild-type

abnormal T-helper 1 physiology ( J:125654 )

• in vivo, Th1 response to MOG is absent unlike in wild-type mice

• in vitro, lymph node cells from mice receiving wild-type MOG T cells exhibit reduced Th1 recall response compared with similarly treated wild-type mice

• in vivo, Th1 response to PLP is reduced compared to in wild-type mice

• in vitro, the frequency of Th1 recall response is greater than in H2-Dma^tm1Luc homozygotes

cellular

decreased T cell proliferation ( J:28966 )

• lymph node cells show significantly lower proliferative responses to immunization with keyhole limpet cyanin (KLH) compared to wild-type