Phenotypes Associated with This Genotype

Genotype
MGI:3688837

• Allelic Composition: Cd74^tm2Liz/Cd74^tm1Liz
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:28966 )

N • compact Aalpha^bAbeta^b dimers are produced efficiently in absence of invariant chain p41 isoform

N • mutants show no significant differences in level of class II expressed on spleen cells compared to wild-type

N • normal numbers of CD4+CD8- T cells are observed compared to Cd74^tm1Liz

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells

abnormal antigen presentation via MHC class II ( J:28966 )

• cell expressing the p31 invariant chain (lacking p41 chain) can present native protein antigens including keyhole limpet cyanin (KLH), ovalbumin (OVA), and IgG2a^a compared to complete invariant chain deficient spleen cells

hematopoietic system

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells

cellular

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells