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Phenotypes Associated with This Genotype
Genotype
MGI:3688721
Allelic
Composition		 Spi1tm2Dgt/Spi1tm2Dgt
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1tm2Dgt mutation (1 available); any Spi1 mutation (30 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal blood cell morphology/development ( J:114150 )
• 2-3 weeks after induction of cre expression with pI-pC, number of HSCs in bone marrow is decreased with loss of CMPs, GMPs and mature myeloid cells while MEPs are increased
• by 6 weeks, numbers of CLPs, CMPs, and GMPs begin to recover

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory