Analysis Tools
mortality/aging
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• die around E10.5
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embryo
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• exhibit decreased cell proliferation in pharyngeal endoderm
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• growth retardation at about E9.5
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• exhibit decreased cell proliferation and increased apoptosis of splanchnic mesodermal cells that are immediately adjacent to pharyngeal endoderm at E8.75 or E9.5
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cardiovascular system
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• lack an outflow tract as indicated by marker analysis
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• cardiac primorida at E8.75 resembles cardiac primordia seen in wild-type at E8.25, suggesting an interruption in heart development
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• hearts are unlooped at E9-9.5
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• exhibit significant reduction in the amount of atrial tissue
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• hearts are misshapen at E9-9.5
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• lack the right ventricle, although cells with left ventricular, A/V canal and atrial identities are present
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digestive/alimentary system
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• exhibit failure of exocrine cell differentiation in the dorsal but not the ventral pancreas
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endocrine/exocrine glands
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• rudimentary pouch forms at E9.5, small and primitive
• pouch cells are aberrant and fail to differentiate
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• at E9.5
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• exhibit failure of exocrine cell differentiation in the dorsal but not the ventral pancreas
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• cultured gut explants do not generate differentiated islet cells
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• exhibit complete absence of islet (glucogon+) cells in E9.5 embryos
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• dorsal pancreatic mesenchyme does not form
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craniofacial
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• exhibit decreased cell proliferation in pharyngeal endoderm
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nervous system
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• rudimentary pouch forms at E9.5, small and primitive
• pouch cells are aberrant and fail to differentiate
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• at E9.5
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