Phenotypes Associated with This Genotype

Genotype
MGI:3688105

• Allelic Composition: Tg(SOD1)2Gur/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Amyotrophic lateral sclerosis-like lesions in the spinal cord of Tg(SOD1)2Gur/0 and Tg(SOD1-G93A)1Gur/0 mice

nervous system

abnormal axon morphology ( J:78629 , J:78630 )

• mild swelling of axons traveling toward the anterior roots at 232 days of age (J:78629)

• numerous small vacuoles in the axoplasm of some swollen axons (J:78629)

• never show any clinical signs of disease at up to 300 days of age (J:78630)

abnormal spinal cord morphology ( J:76718 )

• develop neurofilament-rich spheroids in the spinal cords at much later time (132 days of age) points than Tg(SOD1-G93A)1Gur mutants, however do not appear to develop motor neuron disease