Phenotypes for Disp1 Edil3 Shh MGI:3687546 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Disp1^tm1Pab/Disp1^tm1Pab Shh^tm2Chg/Shh⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1^tm1Pab mutation (0 available); any Disp1 mutation (61 available)
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (44 available)
Shh^tm2Chg mutation (0 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:109101 )

• survive to at least E18.5

limbs/digits/tail

abnormal digit morphology ( J:109101 )

• digits show segmentation and calcification defects

preaxial polydactyly ( J:109101 )

• develop 6-7 digits per limb (preaxial polydactyly)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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