Phenotypes Associated with This Genotype

Genotype
MGI:3687275

• Allelic Composition: Gzmm^tm1(cre)Mjs/Gzmm^tm1(cre)Mjs
• Genetic Background: C57BL/6-Gzmm^tm1(cre)Mjs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Herpesvirales infection ( J:113213 )

• transient increase in viral titers in the spleen and liver at 3 and 4 days post murine cytomegalovirus (MCMV) infection; however by 5 days post infection titers are similar to wild-type

• in the spleen and liver at 3 and 4 days post MCMV infection more cells show signs of cytomegaly, the frequency of viral inclusions is increased, and the extent of tissue damage (characterized by nonspecific hemorrhage) is increased

• however, cytotoxic activity of NK cells, clearance of and resistance to ectromelia viral infection, and clearance of tumor cells (B cell lymphoma) are similar to wild-type