Analysis Tools
homeostasis/metabolism
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• Mapk1 protein levels are decreased ~3-fold at the DN3 stage and from 25-100-fold at the DN4 stage
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immune system
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• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation
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• there is a larger decrease in CD4 T cells than CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
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• there is a decrease in CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
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hematopoietic system
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• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation
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• there is a larger decrease in CD4 T cells than CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
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• there is a decrease in CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
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