Phenotypes Associated with This Genotype

Genotype
MGI:3686782

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Tbx1^tm1Bld/Tbx1^tm5Bld
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:112457 )

N • exhibit rescue of the outflow tract defects, the formation and remodeling of the 3rd and 6th pharyngeal arch arteries and the hypoplasia of the 2nd pharyngeal arch

absent fourth pharyngeal arch artery ( J:112457 )

• exhibit 4th pharyngeal arch artery aplasia

• however, formation and remodeling of the 3rd and 6th pharyngeal arch arteries is rescued

craniofacial

absent fourth pharyngeal arch artery ( J:112457 )

• exhibit 4th pharyngeal arch artery aplasia

• however, formation and remodeling of the 3rd and 6th pharyngeal arch arteries is rescued

absent fourth pharyngeal arch ( J:112457 )

• exhibit 4th pharyngeal arch aplasia

• however exhibit rescue of the 2nd arch hypoplasia

embryo

absent fourth pharyngeal arch artery ( J:112457 )

• exhibit 4th pharyngeal arch artery aplasia

• however, formation and remodeling of the 3rd and 6th pharyngeal arch arteries is rescued

abnormal neural crest cell migration ( J:112457 )

• the neural crest migration and cranial nerve pathway abnormalities are only marginally improved

absent fourth pharyngeal arch ( J:112457 )

• exhibit 4th pharyngeal arch aplasia

• however exhibit rescue of the 2nd arch hypoplasia

hematopoietic system

athymia ( J:112457 )

• absent at E18.5

immune system

athymia ( J:112457 )

• absent at E18.5

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:112457 )

N • exhbiit rescue of the external ear hypolasia

cellular

abnormal neural crest cell migration ( J:112457 )

• the neural crest migration and cranial nerve pathway abnormalities are only marginally improved

endocrine/exocrine glands

athymia ( J:112457 )

• absent at E18.5