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Phenotypes Associated with This Genotype
Genotype
MGI:3665403
Allelic
Composition
Grip1eb/Grip1eb
Genetic
Background
involves: hairless stock
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1eb mutation (1 available); any Grip1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the eye-bulb is absent or very small when a large bleb is present or only slightly reduced in size as a result of a small ruptured bleb (J:12164)
• 258 of 335 show anophthalmia or microphthalmia on one or both sides (J:13412)
• the eye-bulb is absent or very small when a large bleb is present (J:12164)
• 258 of 335 show anophthalmia or microphthalmia on one or both sides (J:13412)

limbs/digits/tail
• a foot may be absent or distorted in direct correlation with the extent and location of the bleb
• 145 of 335 show clubbed feet, webbed toes, or extra digits on one or both sides, usually involving the hind foot
• 145 of 335 show clubbed feet, webbed toes, or extra digits on one or both sides, usually involving the hind foot
• 145 of 335 show clubbed feet, webbed toes, or extra digits on one or both sides, usually involving the hind foot
• a foot may be absent or distorted in direct correlation with the extent and location of the bleb

renal/urinary system
• 158 of 335 show small, missing, or cystic kidneys on one or both sides
• 158 of 335 show small, missing, or cystic kidneys on one or both sides
• 158 of 335 show small, missing, or cystic kidneys on one or both sides

cardiovascular system
• blisters become hemorrhagic during E13-14 and the hemorrhagic blebs show that small vessels have openings into the bleb

integument
• clear blisters of fluid appear in the hypodermis of the eyelids and the apical areas of the limbs during E12-13
• blisters/blebs enlarge and become hemorrhagic during E13-14 and persist during the intrauterine period but rupture soon after birth


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory