Mouse Genome Informatics
hm
    Grip1eb/Grip1eb
involves: hairless stock
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• the eye-bulb is absent or very small when a large bleb is present or only slightly reduced in size as a result of a small ruptured bleb (J:12164)
• 258 of 335 show anophthalmia or microphthalmia on one or both sides (J:13412)
• the eye-bulb is absent or very small when a large bleb is present (J:12164)
• 258 of 335 show anophthalmia or microphthalmia on one or both sides (J:13412)

limbs/digits/tail
• a foot may be absent or distorted in direct correlation with the extent and location of the bleb
• 145 of 335 show clubbed feet, webbed toes, or extra digits on one or both sides, usually involving the hind foot
• 145 of 335 show clubbed feet, webbed toes, or extra digits on one or both sides, usually involving the hind foot
• 145 of 335 show clubbed feet, webbed toes, or extra digits on one or both sides, usually involving the hind foot
• a foot may be absent or distorted in direct correlation with the extent and location of the bleb

renal/urinary system
• 158 of 335 show small, missing, or cystic kidneys on one or both sides
• 158 of 335 show small, missing, or cystic kidneys on one or both sides
• 158 of 335 show small, missing, or cystic kidneys on one or both sides

cardiovascular system
• blisters become hemorrhagic during E13-14 and the hemorrhagic blebs show that small vessels have openings into the bleb

integument
• clear blisters of fluid appear in the hypodermis of the eyelids and the apical areas of the limbs during E12-13
• blisters/blebs enlarge and become hemorrhagic during E13-14 and persist during the intrauterine period but rupture soon after birth

Mouse Models of Human Disease
OMIM IDRef(s)
Clubfoot, Congenital, with or without Deficiency of Long Bones and/or Mirror-Image Polydactyly; CCF 119800 J:13412