Phenotypes Associated with This Genotype

Genotype
MGI:3665269

• Allelic Composition: Aldh1a2^tm1Soc/Aldh1a2^tm2Soc; Isl1^tm1(cre)Tmj/Isl1⁺
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:112635 )

• at E13.5 both ventral and dorsal projecting lateral motor column neurons appear stunted or atrophied and in some cases are retracted

decreased motor neuron number ( J:112635 )

• at E13.5 at the forelimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 30% and 25%, respectively; however no difference in the number of lateral motor column lateral motor neurons is detected at E12.5

• at E13.5 at the hindlimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 17% and 20%, respectively