Phenotypes Associated with This Genotype

Genotype
MGI:3664864

• Allelic Composition: Bdnf^tm1Flee/Bdnf⁺
• Genetic Background: B6.129-Bdnf^tm1Flee

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:113019 )

• impaired context dependent learning but no difference in cue-dependent learning

nervous system

abnormal dentate gyrus morphology ( J:113019 )

• reduction in dendritic arbor complexity at or above 90 uM from the soma

decreased hippocampus volume ( J:113019 )

• 13.7 +/- 0.7% reduction in hippocampal volume

abnormal dendrite morphology ( J:113019 )

• reduction in dendritic arbor complexity at or above 90 uM from the soma in dentate gyrus neurons

abnormal neuron physiology ( J:113019 )

• hippocampal-cortical neurons display a 18 +/- 2% decrease in regulated secretion, but no decrease in constitutive secretion, of BDNF