Phenotypes Associated with This Genotype

Genotype
MGI:3664778

• Allelic Composition: Nodal^tm1.1Dbc/Nodal^tm1.1Dbc
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:112799 )

embryo

abnormal mesendoderm development ( J:112799 )

• expression analysis indicates that mesendodermal progenitor cells are absent

embryonic growth arrest ( J:112799 )

• arrest during gastrulation

abnormal primitive streak formation ( J:112799 )

• the entire epiblast assumes a mesenchymal fate indicating ectopic primitive streak formation