Phenotypes Associated with This Genotype

Genotype
MGI:3664098

• Allelic Composition: Ptpn1^tm2Bbk/Ptpn1⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:111969 )

• male mice heterozygous for Ptpn1^tm2Bbk show reduced body weight on a high fat diet between 9 and 17 weeks of age compared to Ptpn1-sufficient controls

homeostasis/metabolism

decreased circulating glucose level ( J:111969 )

• mutants have lower fed blood glucose on regular chow and HFD vs controls

decreased circulating insulin level ( J:111969 )

• mutants have lower seurm insulin levels on regular chow and HFD vs controls