Phenotypes Associated with This Genotype

Genotype
MGI:3663922

• Allelic Composition: Fev^tm1Esd/Fev^tm1Esd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:81450 )

• small number of deaths within the first week of life

nervous system

abnormal neuron differentiation ( J:81450 )

• serotonin neuron development disrupted in the hindbrain

• precursors formed but most fail to differentiate

• 70% loss of serotinin immunoreactive cell bodies in adult brains

• greatly diminished density of serotonin immunoreactive neurons in the cortex and hippocampus

• B nuclei of the hind brain are missing

behavior/neurological

increased aggression towards mice ( J:81450 )

• shorter latency to attack

increased anxiety-related response ( J:81450 )

• although locomotor activity is normal, mice spend less than normal time in the central areas during an open field test

• never enter the open arms in a plus maze test

impaired coordination ( J:81450 )

• initial rotarod performance poor in comparison to controls

• later performance becomes comparable to controls

cellular

abnormal neuron differentiation ( J:81450 )

• serotonin neuron development disrupted in the hindbrain

• precursors formed but most fail to differentiate

• 70% loss of serotinin immunoreactive cell bodies in adult brains

• greatly diminished density of serotonin immunoreactive neurons in the cortex and hippocampus

• B nuclei of the hind brain are missing