Phenotypes Associated with This Genotype

Genotype
MGI:3663786

• Allelic Composition: Rfng^tm2Tfv/Rfng^tm2Tfv
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:110952 )

• no homozygous mouse survived past birth

craniofacial

short mandible ( J:110952 )

• examined between E18.5 and birth

cleft secondary palate ( J:110952 )

• examined between E18.5 and birth

• the maxillary shelves are more widely spaced than controls

failure of palatal shelf elevation ( J:110952 )

• in homozygotes, palatal shelves have not elevated towards the midline

skeleton

short mandible ( J:110952 )

• examined between E18.5 and birth

limbs/digits/tail

oligodactyly ( J:110952 )

• examined between E18.5 and birth

syndactyly ( J:110952 )

• soft-tissue syndactyly examined between E18.5 and birth

digestive/alimentary system

cleft secondary palate ( J:110952 )

• examined between E18.5 and birth

• the maxillary shelves are more widely spaced than controls

failure of palatal shelf elevation ( J:110952 )

• in homozygotes, palatal shelves have not elevated towards the midline

growth/size/body

cleft secondary palate ( J:110952 )

• examined between E18.5 and birth

• the maxillary shelves are more widely spaced than controls

failure of palatal shelf elevation ( J:110952 )

• in homozygotes, palatal shelves have not elevated towards the midline