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Phenotypes Associated with This Genotype
Genotype
MGI:3663305
Allelic
Composition
Fgf2tm1Bas/Fgf2tm1Bas
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf2tm1Bas mutation (0 available); any Fgf2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• layering in the cerebral cortex is less defined
• statistically reduced neuronal density in layers II-VI
• layers V and VI are particularly thickened
• barrel structures in the barrel field of the S1 area are reduced

hematopoietic system
• deficiency of myeloid precursors

hearing/vestibular/ear
N
• homozygotes exhibit normal inner ear morphogenesis with no detectable abnormalities in adulthood
• in addition, homozygotes show no significant differences in hearing thresholds before and after noise-induced cochlear damage relative to wild-type littermates

homeostasis/metabolism
• wound healing is noticeably slowed but not impaired


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory