Fgf2^tm1Bas
Targeted Allele Detail

Summary

• Symbol: Fgf2^tm1Bas
• Name: fibroblast growth factor 2; targeted mutation 1, Claudio Basilico
• MGI ID: MGI:2384001
• Synonyms: FGF2^-
• Gene: Fgf2 Location: Chr3:37402616-37464255 bp, + strand Genetic Position: Chr3, 18.41 cM, cytoband A2-B
• Alliance: Fgf2^tm1Bas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47664
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassetted deleted a region of exon 1 encoding 59 amino acids and including the splicing donor site. Transcript was undetected in homozygous mutant mice via RT-PCR analysis. Western blot analysis of protein extracts obtained from various organs confirmed the absence of the 3 known isoforms produced from the endogenous locus. (J:47664)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf2 Mutation: 20 strains or lines available

References

• Original: J:47664 Ortega S, et al., Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5672-7
• All: 8 reference(s)