Phenotypes for Fas MGI:3663022 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fas^lpr/Fas^lpr
Genetic Background	NOD.MRL-Fas^lpr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^lpr mutation (39 available); any Fas mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:78679 )

• when mice are injected with islet specific CD8+ T cell clones, Fas^lpr mice are resistant to diabetogenic effect of injected T cells; 0/5 of Fas mutants are diabetic within 20 day observation period, while control NOD littermates become diabetic within 6 days

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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