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Phenotypes Associated with This Genotype
Genotype
MGI:3663021
Allelic
Composition
Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0
Genetic
Background
NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (24 available); any Fas mutation (54 available)
Tg(Ins2-Fasl)24Ach mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when mice are injected with islet-specific CD8+ T cells, 0/5 transgenic Fas-deficient mice become diabetic whereas 5/5 transgenic Fas-sufficient mice develop diabetes 5 days after transfer

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
OMIM:300136
J:81416


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory