Phenotypes Associated with This Genotype

Genotype
MGI:3662677

• Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:87304 )

• 100% die in the neonatal period

growth/size/body

fetal growth retardation ( J:87304 )

cardiovascular system

abnormal cardiovascular system morphology ( J:87304 )

• cardiovascular defects

third pharyngeal arch artery hypoplasia ( J:87304 )

• hypoplastic third pharyngeal arch artery

abnormal truncus arteriosus septation ( J:87304 )

• severe cardiac outflow tract septation and alignment defects

craniofacial

abnormal craniofacial morphology ( J:87304 )

• craniofacial defects

third pharyngeal arch artery hypoplasia ( J:87304 )

• hypoplastic third pharyngeal arch artery

embryo

third pharyngeal arch artery hypoplasia ( J:87304 )

• hypoplastic third pharyngeal arch artery

abnormal neural crest cell apoptosis ( J:87304 )

• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8 into the lateral regions of pharyngeal arch 3 and developing pharyngeal arches 4 and 6

homeostasis/metabolism

cyanosis ( J:87304 )

edema ( J:87304 )

cellular

abnormal neural crest cell apoptosis ( J:87304 )

• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8 into the lateral regions of pharyngeal arch 3 and developing pharyngeal arches 4 and 6