Phenotypes Associated with This Genotype

Genotype
MGI:3656029

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Ube2n^tm1Aki/Ube2n^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:112287 )

• B cells expressing B220, CD38 and CD21 are present in lower numbers

• fewer B cells enter S phase after stimulation with anti-IgM, anti-CD40, LPS or CpG DNA

abnormal spleen marginal zone morphology ( J:112287 )

• width of marginal zone B cell area is smaller than in controls

decreased marginal zone B cell number ( J:112287 )

• mice have a much lower frequency of B220+CD21^hiCD23^low marginal zone B cells

abnormal B cell physiology ( J:112287 )

• mice show defective MAP kinase activation in B cells

increased B cell apoptosis ( J:112287 )

• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40

decreased B cell proliferation ( J:112287 )

• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls

decreased immunoglobulin level ( J:112287 )

• all isotypes except IgG2a and IgG2b are significantly lower than in controls

abnormal humoral immune response ( J:112287 )

• after immunization with TNP-ficoll or TNP-chicken gammaglobulin mice produce less serum TNP-specific IgM and IgG3

hematopoietic system

decreased B cell number ( J:112287 )

• B cells expressing B220, CD38 and CD21 are present in lower numbers

• fewer B cells enter S phase after stimulation with anti-IgM, anti-CD40, LPS or CpG DNA

abnormal spleen marginal zone morphology ( J:112287 )

• width of marginal zone B cell area is smaller than in controls

decreased marginal zone B cell number ( J:112287 )

• mice have a much lower frequency of B220+CD21^hiCD23^low marginal zone B cells

abnormal B cell physiology ( J:112287 )

• mice show defective MAP kinase activation in B cells

increased B cell apoptosis ( J:112287 )

• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40

decreased B cell proliferation ( J:112287 )

• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls

decreased immunoglobulin level ( J:112287 )

• all isotypes except IgG2a and IgG2b are significantly lower than in controls

cellular

increased B cell apoptosis ( J:112287 )

• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40

decreased B cell proliferation ( J:112287 )

• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls