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Phenotypes Associated with This Genotype
Genotype
MGI:3656028
Allelic
Composition		 Ube2ntm1Aki/Ube2ntm1Aki
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Ube2ntm1Aki mutation (0 available); any Ube2n mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:112287 )
• upon TLR ligand stimulation, macrophages produce less TNF,Il-6 and Il-12p40 than those in conrols

hematopoietic system
abnormal macrophage physiology ( J:112287 )
• upon TLR ligand stimulation, macrophages produce less TNF,Il-6 and Il-12p40 than those in conrols

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory