Phenotypes Associated with This Genotype

Genotype
MGI:3655856

• Allelic Composition: Gnas^tm1Gwa/Gnas⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:70175 )

• mutants take twice as long to regain their righting reflex as wild-type in response to sedative effects of ethanol

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:70175 )

• adenylate cyclase activity stimulated by GTP or AlF in membranes of the nucleus accumbens is significantly reduced relative to wild-type membranes; AlF-stimulated adenylate cyclase activity is also reduced in the hypothalamus (-30%), cerebellum (-23%), hippocampus (-35%), frontal cortex (-22%) and brainstem (-21%)