Mouse Genome Informatics
cx
    Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Tyrc-2J/Tyrc-2J

B6.Cg-Tyrc-2J Cyp1b1tm1Gonz
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• Background Sensitivity: albino Tyrc-2J homozygous mice have severe and more extensive angle developmental defects than pigmented Cyp1b1tm1Gonz/Cyp1b1tm1Gonz mice
• L-dopa administered via pregnant mother throughout ocular development prevents the severe angle dysgenesis
• a small or absent Schlemm's canal
• basal lamina extends from the cornea over the trabecular meshwork
• attachments of the iris to the trabecular meshwork and peripheral cornea

Mouse Models of Human Disease
OMIM IDRef(s)
Glaucoma 3, Primary Congenital, A; GLC3A 231300 J:82280