About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3655823
Allelic
Composition
Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Tyrc-2J/Tyrc-2J
Genetic
Background
B6.Cg-Tyrc-2J Cyp1b1tm1Gonz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1tm1Gonz mutation (3 available); any Cyp1b1 mutation (12 available)
Tyrc-2J mutation (12 available); any Tyr mutation (367 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Background Sensitivity: albino Tyrc-2J homozygous mice have severe and more extensive angle developmental defects than pigmented Cyp1b1tm1Gonz/Cyp1b1tm1Gonz mice
• L-dopa administered via pregnant mother throughout ocular development prevents the severe angle dysgenesis
• a small or absent Schlemm's canal
• basal lamina extends from the cornea over the trabecular meshwork
• attachments of the iris to the trabecular meshwork and peripheral cornea

Mouse Models of Human Disease
OMIM ID Ref(s)
Glaucoma 3, Primary Congenital, A; GLC3A 231300 J:82280


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory