Phenotypes Associated with This Genotype

Genotype
MGI:3655823

• Allelic Composition: Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz; Tyr^c-2J/Tyr^c-2J
• Genetic Background: B6.Cg-Tyr^c-2J Cyp1b1^tm1Gonz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal iridocorneal angle ( J:82280 )

• Background Sensitivity: albino Tyr^c-2J homozygous mice have severe and more extensive angle developmental defects than pigmented Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz mice

• L-dopa administered via pregnant mother throughout ocular development prevents the severe angle dysgenesis

absent Schlemm's canal ( J:82280 )

• a small or absent Schlemm's canal

abnormal trabecular meshwork morphology ( J:82280 )

• basal lamina extends from the cornea over the trabecular meshwork

anterior iris synechia ( J:82280 )

• attachments of the iris to the trabecular meshwork and peripheral cornea

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
buphthalmos		DOID:11211	OMIM:231300	J:82280