Analysis Tools
behavior/neurological
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• in the Y-maze task requiring working memory or attention, mice display impaired spontaneous alternation performance, however show normal spatial learning
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• tend to show lower levels of acoustic startle responses than wild-type at lower pulse intensities, however the acoustic prepulse inhibition is not impaired
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• exhibit better motor coordination a the highest rotating speed of the rotarod, however locomotor activity and swimming ability in the water maze are normal
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muscle
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• exhibit stronger muscle tone in the traction meter test
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nervous system
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• MK-801, an NMDA receptor antagonist, fails to produce acoustic prepulse inhibition deficits as in wild-type, however under basal conditions, acoustic prepulse inhibition is not impaired
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