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Phenotypes Associated with This Genotype
Genotype
MGI:3653919
Allelic
Composition
Hprt1tm1Dhm/Y
Plntm1Egk/Plntm1Egk
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1Dhm mutation (0 available); any Hprt1 mutation (1280 available)
Plntm1Egk mutation (7 available); any Pln mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
• under baseline conditions, left ventricular myocytes exhibit faster calcium transient decays than wild-type, however they are slower than in single homozygous Pln mutant mice

muscle
• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory