Phenotypes Associated with This Genotype

Genotype
MGI:3653918

• Allelic Composition: Hprt1^tm1Dhm/Hprt1^tm1Dhm; Pln^tm1Egk/Pln^tm1Egk
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased cardiac muscle contractility ( J:106044 )

♀ • isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse

abnormal cardiac muscle relaxation ( J:106044 )

♀ • isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice

abnormal myocardial fiber physiology ( J:106044 )

♀ • under baseline conditions, left ventricular myocytes exhibit faster calcium transient decays than wild-type, however they are slower than in single homozygous Pln mutant mice

muscle

increased cardiac muscle contractility ( J:106044 )

♀ • isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse

abnormal cardiac muscle relaxation ( J:106044 )

♀ • isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice