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Phenotypes Associated with This Genotype
Genotype
MGI:3653879
Allelic
Composition		 Erap1tm1Iay/Erap1tm1Iay
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erap1tm1Iay mutation (0 available); any Erap1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytotoxic T cell physiology ( J:111047 )
• CD8+ T cell responses to viral epitopes is altered compared to wild-type; 8-mer epitopes of LCMV show reduced immunogenicity in mutants while an 11-mer shows increased immunogenicity; vaccinia virus epitope B8R shows increased immunogenicity in mutants compared to wild-type
decreased level of surface class I molecules ( J:111047 )
• splenocytes from mutants have reduced MHC Class I levels on their surfaces

hematopoietic system
abnormal cytotoxic T cell physiology ( J:111047 )
• CD8+ T cell responses to viral epitopes is altered compared to wild-type; 8-mer epitopes of LCMV show reduced immunogenicity in mutants while an 11-mer shows increased immunogenicity; vaccinia virus epitope B8R shows increased immunogenicity in mutants compared to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory