Erap1^tm1Iay
Targeted Allele Detail

Summary

• Symbol: Erap1^tm1Iay
• Name: endoplasmic reticulum aminopeptidase 1; targeted mutation 1, Ian A York
• MGI ID: MGI:3653695
• Gene: Erap1 Location: Chr13:74787692-74841324 bp, + strand Genetic Position: Chr13, 40.48 cM, cytoband C1
• Alliance: Erap1^tm1Iay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111047
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 5 and 6 were removed via cre-mediated recombination, resulting in a frame shift that would lead to early termination of the exon 4 exon 7 fusion. The protein if expressed would not be enzymatically active as the active site is in exon 5. (J:111047)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erap1 Mutation: 59 strains or lines available

References

• Original: J:111047 York IA, et al., Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9202-7
• All: 5 reference(s)